Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization† †Electronic supplementary information (ESI) available: Experimental procedures, list of all the synthesized peptides and their % hIAPP fibrillization inhibition, MTT cytotoxicity assay, crystallization, details of X-ray structure determination, in silico docking of FGAΔFI with hIAPP, CD studies, Tables S1–S4, and Fig. S1–S6. CCDC 822015 and 904790. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3cc38982kClick here for additional data file. Click here for additional data file.

Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization†

Type 2 Diabetes Mellitus (T2DM) is one of the most prevalent endocrine disorders underlining the importance of developingmolecular therapies to mitigate T2DM. It is characterized by a significant decrease in b-cell mass, insulin resistance and presence of amyloid plaques in which human islet amyloid polypeptide (hIAPP) is the major protein component. hIAPP is a 37-residue polypeptide co-secrete...

Homochiral self-assembly of biocoordination polymers: anion-triggered helicity and absolute configuration inversion† †Electronic supplementary information (ESI) available: Preparation and physical characterization data of 1P and 2M, additional structural description, UV-Vis and CD spectra (Fig. S1–S7), crystallographic refinement details for 1P and 2M (Table S1), selected bond distances and angles for 1P and 2M (Tables S2–S5), ESI(+)-MS and ESI(+)-MSMS spectra (Fig. S8–S11 and Schemes S1 and S2) and PXRD (Fig. S12). CCDC 1046609 and 1046610. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc01089f Click here for additional data file. Click here for additional data file.

Very bright mechanoluminescence and remarkable mechanochromism using a tetraphenylethene derivative with aggregation-induced emission† †Electronic supplementary information (ESI) available: Details of the synthesis; structural information for the compound (NMR, IR, and mass spectra); Tables S1–S5; Fig. S1–S11. CCDC 1037840 and 1057432. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc00466g Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

PCFM Lab, GD HPPC Lab, Guangdong Eng High-performance Organic and Polymer P Laboratory of Opto-electronic Material and Chemical Engineering, Sun Yet-sen Univers [email protected]; [email protected] 20 84112222; Tel: +86 20 84112712 State Key Laboratory of Optoelectronic Mat and Engineering, Sun Yat-sen University, Gu Shenzhen China Star Optoelectronics Techn TCL Corporate Research, Guangdon...

Large ring-forming alkylations provide facile access to composite macrocycles† †Electronic supplementary information (ESI) available: Fig. S1–S4, list of macrocycles prepared, experimental procedures, and spectroscopic data. CCDC 1023942. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc03848g Click here for additional data file. Click here for additional data file.

Macrocyclic compounds have potential to enable drug discovery for protein targets with extended, solventexposed binding sites. Crystallographic structures of peptides bound at such sites show strong surface complementarity and frequent aromatic side-chain contacts. In an effort to capture these features in stabilized small molecules, we describe a method to convert linear peptides into constrai...

Insight into the strong aggregation-induced emission of low-conjugated racemic C6-unsubstituted tetrahydropyrimidines through crystal-structure–property relationship of polymorphs† †Electronic supplementary information (ESI) available: General method, instruments, preparation of polymorphs, characterization data, 1H and 13C NMR of THP 3, Table S1 and S2, Fig. S1–S4, “cif” files containing single-crystal X-ray diffraction data of 2c, 2c', 3p, 3b and 3c. CCDC 850811, 1011037–1011040. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc01226k Click here for additional data file. Click here for additional data file.

School of Pharmaceutical Sciences, Southe Avenue North, Guangzhou 510515, China. E Department of Physics, The Hong Kong Un Water Bay, Kowloon, Hong Kong. E-mail: ph Guangdong Innovative Research Team, Materials and Devices, South China Unive China Department of Chemistry, State Key Labora of Molecular Functional Materials, The Technology, Clear Water Bay, Kowloon, Hon † Electronic supplementary...